منابع مشابه
Stress Models of Depression: A Question of Bad Timing
Current antidepressant pharmacotherapy remains unsatisfactory because of its limited adherence and partial therapeutic efficacy. Accordingly, there is a crucial need of validated animal models that fully reflect the nature of the disease and do not only separate facets of the disorder. We read with great interest the recent publication of Mul et al. (2016) reporting that, although the 5 d force...
متن کاملWhen Clocks Go Bad: Neurobehavioural Consequences of Disrupted Circadian Timing
Progress in unravelling the cellular and molecular basis of mammalian circadian regulation over the past decade has provided us with new avenues through which we can explore central nervous system disease. Deteriorations in measurable circadian output parameters, such as sleep/wake deficits and dysregulation of circulating hormone levels, are common features of most central nervous system disor...
متن کاملBad Theory, Bad Practice: Bad Ethics
A profession that claims to understand economies, and that has gained power over the greater part of our societies, has big responsibilities. The fundamental responsibility is to ensure its perception of economies gives some useful guidance to the behaviour of real economies. Here mainstream economics fails utterly, and has been failing for a long time. Worse, it actively resists alternative vi...
متن کاملIt's All in the Timing: Too Much E2F Is a Bad Thing
E2F is one of the best-known cell cycle– dependent transcription factors. The family of E2F proteins have been highly conserved during evolution and function as both transcriptional activators and repressors. In most animals, E2F-mediated activation is a key driver of cell proliferation, and deregulation of E2F is found in most types of cancers. In addition to its proliferation-promoting proper...
متن کاملRecent Salmon Declines: A Result of Lost Feeding Opportunities Due to Bad Timing?
As the timing of spring productivity blooms in near-shore areas advances due to warming trends in global climate, the selection pressures on out-migrating salmon smolts are shifting. Species and stocks that leave natal streams earlier may be favoured over later-migrating fish. The low post-release survival of hatchery fish during recent years may be in part due to static release times that do n...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: K&K - Kultur og Klasse
سال: 1993
ISSN: 2246-2589,0905-6998
DOI: 10.7146/kok.v20i73.20563